Regulation of Inflammatory NF-kB Target Gene Activation by Jak-STAT Signaling

Signaling to NF-kB: Regulation by Ubiquitination

The NF-kB pathway is a ubiquitous stress response that activates the NF-kB family of transcription factors. Antigen receptors, receptors of the innate immune system, and certain intracellular stressors are potent activators of this pathway. The transcriptional program that is activated is both antiapoptotic and highly proinflammatory. Indeed, any compromise in engagement of the pathway results ...

The Jak-Stat Signaling Pathway of Interferons System: Snapshots

Interferons (IFNs) are a family of small regulatory glycoproteins that play a central role in the defense against viral infections. Although IFNs have been initially discovered as antiviral factors, today they are known as an integral part of the cytokine network that affect a wide range of biological processes. IFNs exert their pleiotropic effects through their multisubunit cell surface recept...

SnapShot: JAK-STAT Signaling

NF-kB: Regulation by Methylation

In normal cells exposed to stress, the central transcription factor NF-kB is activated only transiently, to modulate the activation of downstream immune responses. However, in most cancers, NFkB is abnormally activated constitutively, contributing thus to oncogenesis and tumor progression. Therefore, downregulating NF-kBactivity is an important goal of cancer treatment. In order to control NF-k...

Cross-Regulation of JAK-STAT Signaling: Implications for Approaches to Combat Chronic Inflammatory Diseases and Cancers